Keyboard Maestro organizes your macros into Macro Groups which are like folders of macros. Each Macro Group contains a number of macros.
Macro Groups control when the contained macros are active.
A Macro Group can target or exclude specific applications, which means the macros it contains will only be active in those desired applications 1).
By default, Macro Groups and their Macros are active in all applications, that is they are always ready to be triggered.
To have macros only active in specific applications, place the macros in a Macro Group, set it to be active in only specific applications and specify the desired applications.
For example, you could have macros targeted at:
Alternatively, to have macros active everywhere except specific applications, place them in a Macro Group, set it to be active in all except specific applications and add the desired applications to the list 2).
By choosing in which applications a macro is active in, you can control more applications with fewer conflicts.
A Macro Group can also act as a container for specific-use macros which are enabled only after a Hot Key press or which are displayed as a palette of the macros 3).
Macro Groups can be displayed as a palette giving you a way to build custom toolbars.
To have the Macros in a Macro Group always ready to be triggered, set the Macro Group to be activated Always activated. This is the default and you only need to change it if you want to set a group of Macros to be available in a macro palette or after you specifically activate them.
To have Macros that are active once only when you specifically activate them, set the Macro Group to be Activated for one action. The Macros in the Macro Group will be enabled when you press the Macro Group Hot Key and will remain enabled only until either any macro is triggered or you press any other key 4).
To have Macros that are active after you specifically activate them, set the Macro Group to be Activated/deactivated. The Macros in the Macro Group will be enabled when you press the Macro Group Hot Key and will remain enabled until you press the Macro Group Hot Key again 5).
To have Macros that are active and displayed only after you specifically activate them, set the Macro Group to Show a palette for one action. The Macros in the Macro Group will be displayed in a floating Macro Palette and enabled when you press the Macro Group Hot Key and will remain displayed until either any macro is triggered or you press any other key 6).
To have Macros that are active and displayed after you specifically activate them, set the Macro Group to Show/hide a palette. The Macros in the Macro Group will be displayed in a floating Macro Palette and enabled when you press the Macro Group Hot Key and will remain displayed until you press the Macro Group Hot Key again. You could use this to create a set of related actions that do not even need a Hot Key 7).
To have Macros that are always active and displayed in a palette, set the Macro Group to Show a palette. The Macros in the Macro Group will be displayed in a floating Macro Palette and enabled. The palette will close when you press the Macro Group Hot Key and will remain closed (and the macros disabled) until you press the Macro Group Hot Key again 8).
By choosing how you activate the Macro Group, you can create sets of Macros for many different purposes.
If you are syncing your macros with another Mac, Macro Groups can be disabled specifically on this Mac.
See also these forum topics:
Macro group - Activated vs Palette