Although it is generally better to use high level actions like Press Button or Resize Window, it is sometimes necessary to resort to looking at the screen for a specific image and responding appropriately (behaving differently if it exists, clicking on it, moving things to it, etc).
There are various actions (Move or Click Mouse, Find Image on Screen), conditions and collections that search the screen for a matching image.
Remember when specifying the area, as with all numeric fields, the numbers can be calculations including functions, and the fields expand to allow for longer expressions as soon as you type something other than a number, so this allows very precise control of where you can match.